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Sanofi, GSK Commence Clinical Trial of COVID-19 Vaccine

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Sanofi and GSK have announced the commencement of Phase 1/2 clinical trial for their adjuvanted COVID-19 vaccine.

The vaccine candidate that was developed by both firms uses the same recombinant protein-based technology as one of Sanofi’s seasonal influenza vaccines with GSK’s established pandemic adjuvant technology.

The companies in a statement said that the Phase 1/2 clinical trial is a randomised, double blind and placebo-controlled trial.

It is designed to evaluate the safety, reactogenicity and immunogenicity of the vaccine candidate.

They added that a total of 440 healthy adults are being enrolled in the trial across 11 investigational sites in the United States.

The companies anticipate first results in early December 2020, to support the initiation of a Phase 3 trial in December 2020.

“If these data are sufficient for licensure application, we are planning to request regulatory approval in the first half of 2021,” the statement said.

Speaking on the development, Executive Vice President and Global Head of Sanofi Pasteur, Thomas Triomphe, said, “Sanofi and GSK bring proven science and technology to the fight against the global COVID-19 pandemic, with the shared objective of delivering a safe and effective vaccine.

“The initiation of our clinical study is an important step and brings us closer to a potential vaccine which could help defeat COVID-19. Our dedicated teams and partner continue to work around the clock as we aim to deliver the first results in early December. Positive data will enable a prompt start of the pivotal phase 3 trial by the end of this year.”

Also speaking, President of GSK Vaccines, Roger Connor, said, “Moving this vaccine candidate into clinical development is an important moment in the progress towards addressing the global pandemic we are all facing.

“This builds on the confidence shown by governments already in the potential of this protein- based adjuvanted vaccine candidate, which utilises established technology from both companies, and can be produced at scale by two of the leading vaccine manufacturers globally.

“We now look forward to the data from the study, and if positive, beginning a Phase 3 trial by the end of the year.”

Sanofi is leading the clinical development and registration of the COVID-19 vaccine.

Pre-clinical data showed an acceptable reactogenicity profile and data based on two injections of the adjuvanted recombinant vaccine showed high levels of neutralising antibodies that are comparable to levels in humans who recovered from the COVID-19 infection.

Pre-clinical results will be published later this year. In parallel, Sanofi and GSK are scaling up manufacturing of the antigen and adjuvant with the target of producing up to one billion doses in 2021.

CEO/Founder Investors King Ltd, a foreign exchange research analyst, contributing author on New York-based Talk Markets and Investing.com, with over a decade experience in the global financial markets.

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Feminist Coalition Puts an End to Donations, Raises N147.8 Million

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Feminist Coalition Raises N147.8 Million in 14 Days, Halts Donations

Feminist Coalition, a non-governmental group at the forefront of #EndSARs protest, has asked all potential donors to stop sending money to the account following the clampdown on protesters.

In a statement titled “A Statement from the Feminist Coalition” and co-signed by Damilola Odufuwa, Odunayo Eweniyi, Layo Ogunbanwo, Ozzy Etomi, Ire Aderinokun, Fakhrriyyah Hashim, Oluwaseun Osowobi, Jola Ayeye, Laila Johnson-Salami, Karo Omu, Obiageli Alintah, Tito Ovia, Kiki Mordi and FK Abudu.

The statement said the group raised a total of N147.8 million in donations in USD, CAD, GBP, EUR, GHS, KES, and BTC.

A total of ₦60.4 million was spent on protesters and victims brutalised by the police. The group said a total of ₦87.5 million is left.

* Total received – ₦147,855,788.28 (includes donations in USD, CAD, GBP, EUR, GHS, KES, and BTC)

* Total disbursed – ₦60,403,235.00

* Total left – ₦87,452,553.28

It stated, “The funds were raised through the generosity of well-meaning people and concerned Nigerians who want their voices to be heard and their demands to be met.

The group said it decided to halt all donations after President Muhammadu Buhari’s speech on Thursday.

The rest of the donations will go towards funding medical emergencies, legal aid for wrongfully detained citizens, and relief for victims of police brutality and families of the deceased.

“The past two weeks have been tough for many Nigerians, most especially the last two days. Many lives have been lost and properties destroyed at the height of what started as peaceful marches for the end to police brutality.

“The Feminist Coalition condoles with every Nigerian mother, father, son, daughter who has lost a loved one in these trying times. These Nigerians share the same vision for a better country as we all do and should be duly recognized as heroes.

“Following the President’s address, we hereby encourage all young Nigerians to stay safe, stay home, and observe the mandated curfew in your state.

“The Feminist Coalition has made a decision to henceforth stop all donation inflows for the #EndSARS peaceful protest. The rest of the donations will go towards funding medical emergencies, legal aid for wrongfully detained citizens, and relief for victims of police brutality and families of the deceased.”

Below is the official statement.

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#EndSARS: Protesters Converge at Lekki Toll Gate Despite Sanwo-Olu 24 Hour Curfew

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#EndSARS Protesters Gathered at Lekki Toll Gate Despite Curfew

Lagos protesters defied the 24-hour curfew imposed by the executive governor of Lagos State, Babajide Sanwo-Olu, as they gathered at Lekki Tollgate to continue their agitation.

The peaceful #EndSARS protesters sang the nation’s national anthem as they held on to their Nigerian flags proudly.

Earlier today, governor Sanwo-Olu, had imposed a 24-hour curfew across all parts of the state, saying the peaceful protest has been hijacked by criminals and unscrupulous individuals.

In a statement put out by the governor, he said “I have watched with shock how what began as a peaceful #EndSARS protest has degenerated into a monster that is threatening the well-being of our society.

“Lives and limbs have been lost as criminals and miscreants are now hiding under the umbrella of these protests to unleash mayhem on our state. As a government that is alive to its responsibility and has shown a commitment to the movement #ENDSARS, we will not watch and allow anarchy in our dear state.”

“I, therefore, hereby impose a 24-hour curfew on all parts of the State as from 4pm today, 20th October,2020. Nobody, except essential service providers and first responders must be found on the streets.

However, the determined Nigerian youths matched forward as they clamoured for complete police reform and a broad-based transparent and good governance for all Nigerians and not a selected few.

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Lagos Imposes 24 Hour Curfew as #EndSARS Protest Turns Violent

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Sanwo-Olu Imposes 24 Hour Curfew in Lagos as Hoodlums Hijacked #EndSARS Protests

The Executive Governor of Lagos, Babajide Sanwo-Olu, on Tuesday, imposed a 24-hour curfew on all parts of the state as peaceful #EndSARS protest turned violence amid the destruction of properties and lives.

In a statement released by the governor through his official Twitter account @jidesanwoolu, the governor said “I have watched with shock how what began as a peaceful #EndSARS protest has degenerated into a monster that is threatening the well-being of our society.

“Lives and limbs have been lost as criminals and miscreants are now hiding under the umbrella of these protests to unleash mayhem on our state. As a government that is alive to its responsibility and has shown a commitment to the movement #ENDSARS, we will not watch and allow anarchy in our dear state.”

“I, therefore, hereby impose a 24-hour curfew on all parts of the State as from 4pm today, 20th October,2020. Nobody, except essential service providers and first responders must be found on the streets.”

This was after reports of numerous attacks and destruction of properties by certain elements that the Nigerian youths claimed were sponsored by politicians to disrupt their agitation and invalidate the entire protest.

On Monday, prisoners were freed in Benin, Edo State by unknown individuals either sponsored by politicians or part of the protesters that gone rogue or with different agenda.

In Abuja, a group of thugs (sponsored or not) burnt several vehicles claimed to be parked by peaceful protesters while in Lagos, the story is not different as unscrupulous elements have been stealing and attacking people.

With a 24-hour curfew now in place in Lagos and Edo States, the youths agitating may be forced to eventually meet with the government to discuss their demands and implementation methodology.

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